Figure 2
From: Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Multiple alignment of amino acid sequences from four Plasmodium DHFRs. Secondary structure (cylinders and arrows represent helices and strands, respectively) is indicated based on the crystal structure of P. vivax DHFR (PDB entry 2BL9). Yellow highlighting represents identical amino acids across the four sequences. Conserved residues in the pyrimethamine binding site of P. vivax DHFR are indicated by a red star.