Figure 6From: Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria modelsEffects of P. berghei infection on iNOS mRNA expression in mice liver and spleen. Expression of iNOS mRNA in the liver and spleen of DBA-2 (A and B, N = 3) and C57BL/6 (C and D, N = 4) mice infected with P. berghei (ANKA), when parasitaemia rates rose to levels >30%PE (DBA-2) on PID20 or >20%PE (C57BL/6) on PID10 and respective non-infected controls (N = 3). For comparative purposes, levels of iNOS mRNA were also determined in the liver (A, N = 6) and spleen (B, N = 5) of non-infected DBA-2 mice treated with E. coli LPS (5 mg/kg i.p. 12 hours earlier). Column height represents mean ± S.E.M. for relative levels of mRNA. Differences (Mann-Whitney U test, P < 0.05) between infected (malaria) and non-infected control (Ctrl) are indicated by an asterisk (*). Quantification of mRNA was by real time RT-PCR.Back to article page