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Table 1 Phase-II enzyme activity, glutathione and TBARS in the liver of P.berghei-infected mice

From: Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models

Parameters

GST

UGT

GSH

TBARS

Sub-cellular fraction

m

c

m

c

-

DBA-2

Infected

(N)

80.4 ± 4.5

(8)

700 ± 100

(8)

8.4 ± 3.2

(8)

86.0 ± 8.0

(7)

13.5 ± 3.9

(5)

 

Control

(N)

91.0 ± 5.4

(8)

800 ± 100

(8)

9.0 ± 3.0

(8)

76.9 ± 9.0

(7)

39.0 ± 5.5*

(5)

C57BL/6

Infected

(N)

85.6 ± 6.1

(8)

1 400 ± 100

(6)

7.4 ± 3.7

(9)

35.0 ± 9.8

(6)

19.5 ± 2.7

(5)

 

Control

(N)

95.9 ± 2.7

(8)

1 500 ± 100

(8)

5.5 ± 3.0

(9)

16.9 ± 8.6*

(8)

23.6 ± 12.3

(5)

  1. Data are mean ± S.E.M. m: microsomal fraction; c: cytosolic fraction; (N): number of animals. Values different from those for non-infected controls (Student's t test, P < 0.05) are indicated by an asterisk (*). Enzyme activities are expressed as nmol/mg ptn/min (mGST and UGT) and μmol/mg ptn/min (cGST). GSH as nmol/mg ptn; TBARS as nmol MDA/g wet tissue.