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Table 3 Examples of distributions describing vaccine response in order of increasing heterogeneity.

From: Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

Vaccine

Description

leaky

Vaccination gives everyone the same level of partial protection.

leaky-or-nothing

Vaccination offers partial protection to some people but no protection to others, as described by Halloran et al [27].

beta

Vaccination offers a variable level of protection to all vaccinees. The effect of vaccination follows a beta distribution as described by Maire et al [21].

all-or-nothing

Vaccination offers full protection to some people but no protection to others.