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Table 4 Protective effect of polymorphisms in the genes of IL12A and its receptor, IL12RB1, against severe anaemia, severe anaemia with any parasitaemia and high-density parasitaemia

From: Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

 

Crude incidence/1000 person-months

Adjusted risk ratio (95% CI)a

IL12 A-rs2243138b

AA

AT

TT

TT vs (AA + AT)

P

Severe anaemia episodes

38.3

41.3

30.3

0.69 (0.53-0.89)

.004

Severe anemia with any parasitaemia episodes

32.8

35.8

24.5

0.66 (0.49-0.89)

.004

IL12RB1-rs383483c

AA

AG

GG

AG vs (AA+GG)

P

High-density parasitaemia episodes

155.2

172.8

146.8

1.21 (1.07-1.36)

.003

  1. NOTE.
  2. a Adjusted by sickle cell type and treatment with anti-malarial drugs.
  3. b A dominant model used for IL12 A-rs2243138.
  4. c A heterozygous advantage model used for IL12RB1-rs383483.
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Malaria Journal

ISSN: 1475-2875

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