Figure 2
Splenic CD11c(+) cells from semi-immune mice lowered parasitaemia, enhanced anti- P. berghei IgG1 level and improved the ECM survival rate in recipient mice. (A) Plots show the representative purity of CD11c(+) cells. (B) Survival curves for mice that received 106 splenic CD11c(+) cells and for PBS-treated control mice (n = 16-18 mice/group). Data shown are pooled from three independent experiments. Significant differences between groups as determined by log-rank test are indicated by symbols: *P < 0.05 for SI11c vs Na11c; $P < 0.05 for SI11c vs PBS. (C) Bar chart showing the median parasitaemia (%) of recipient mice over the time of infection (n = 6-9 mice/group). Parasitaemia (%) of these groups of mice was performed on days post challenge as indicated and was shown by the box-plots. Data shown are representative of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001, Mann–Whitney U test. (D) Median levels of plasma anti-P. berghei IgG1, IgG2a and IgG2b were determined on day 5 post-infection in mice with adoptively transferred DCs. Data are representative of two separate experiments (n = 4 mice/group). *P < 0.05, Mann–Whitney U test.