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Table 3 Robustness results for chloroquine and primaquine obtained by UPLC method

From: Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method

Conditions

Chloroquine

Primaquine

Mean content (%)

R.S.D. (%)

Retention time (min)

Mean content (%)

R.S.D. (%)

Retention time (min)

Nominal*

99.65

0.77

1.00

99.87

0.36

1.31

Acetonitile concentration 8-38%

98.72

1.22

1.08

98.05

1.00

1.45

Acetonitile concentration 12-42%

98.36

1.04

0.73

98.86

1.15

1.27

Mobile phase pH 2.7

99.02

0.92

1.01

98.69

0.50

1.28

Mobile phase pH 3.3

100.53

1.15

1.02

99.12

0.88

1.34

Temperature 23°C

99.97

1.17

1.01

99.11

1.07

1.33

Temperature 27°C

100.42

0.99

0.99

99.26

0.74

1.31

  1. *Acetonitrile concentration in gradient 10-40%, mobile phase pH 3.0, temperature 25°C.