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Table 4 Hematological values of 38 days EEHa-treated mice

From: Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

Hematological parameters

Males (n = 8)

Females (n = 8)

C

T200

T100

S

C

T200

T100

S

WBC (10 3 /mm 3 )

6.0 ± 1.6

10.0 ± 2.8

10.0 ± 1.6

7.9 ± 3.0

4.6 ± 0.4

5.4 ± 1.5

6.3 ± 1.4

14.5 ± 2.1*

RCB (10 6 /mm 3 )

6.5 ± 2.3

7.4 ± 0.7

7.8 ± 0.5

7.8 ± 0.7

5.0 ± 0.6

5.1 ± 0.8

7.6 ± 0.3*

7.9 ± 0.5*

Hb (g/dL)

12.1 ± 3.9

11.8 ± 1.3

12.9 ± 0.6

12.9 ± 1.4

7.8 ± 1.1

8.3 ± 0.9

13.0 ± 0.7*

13.3 ± 0.9*

Hem (%)

35.8 ± 1.1

35.1 ± 2.6

39.2 ± 0.9

39.6 ± 4.0

24.0 ± 2.5

25.2 ± 3.2

39.3 ± 1.5*

40.8 ± 2.5*

MCV (fL)

48.6 ± 1.6

49.1 ± 0.7

49.4 ± 0.9

50.5 ± 0.6

48.3 ± 0.7

48.8 ± 1.4

52.0 ± 0.5*

51.5 ± 0.6*

MCH (pg)

16.5 ± 1.1

16.0 ± 0.6

16.4 ± 0.7

16.3 ± 0.4

15.8 ± 0.7

15.9 ± 0.6

16.9 ± 0.7

16.8 ± 0.3

HCMC (g/dL)

33.6 ± 1.1

32.4 ± 0.6

32.9 ± 0.5

32.4 ± 0.4

31.8 ± 0.5

32.7 ± 0.5

32.9 ± 0.7*

32.6 ± 0.5

Plat (10 3 /mm 3 )

244.5 ± 63.0

445.3 ± 74*

403.0 ± 53.7

400.0 ± 145.1

283.3 ± 7.8

207.0 ± 43.4

346.0 ± 49.5

403.3 ± 161

  1. EEHa: Ethanol extract from Himatanthus articulatus stem bark; WBC- white blood cell count; RCB- red blood cell count; Hb- hemoglobin; Hem- hematocrit; MCV- mean corpuscular volume; HCM- mean corpuscular hemoglobin; CHCM- mean corpuscular hemoglobin concentration; Plat- platelets; C- control group; T200- group treated orally with EEHa (200 mg/Kg); T100- group treated orally with EEHa (100 mg/Kg); S- satellite group. *p < 0.05 versus control group.