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Table 3 Protective efficacy of DHA/PQ when stratified by PQ exposure

From: Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

Treatment arm PQ strataa N Number of cases PYAR Incidence of malaria Univariate Multivariateb
PE (95 % CI) p value PE (95 % CI) p value
No chemoprevention 89 723 105.9 6.83
Low 40 242 50.7 4.77 31 % (5–50 %) 0.023 31 % (6–49 %) 0.017
Monthly DHA/PQ Medium 37 115 50.8 2.26 67 % (53–77 %) <0.001 67 % (54–76 %) <0.001
High 10 3 15.0 0.20 97 % (91–99 %) <0.001 97 % (89–99 %) <0.001
  1. DHA/PQ dihydroartemisinin/piperaquine, PYAR person years at risk, PE protective efficacy
  2. aPQ strata based on average PQ exposure score [0 to <1 (“low”), 1 to <2 (“medium”), and >2 (“high”)]
  3. bMultivariate model includes housing location, type, maternal age, and education level of primary care giver