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Table 3 Comparison of percentage Transmission-Reducing Activity using 2 Pf strains of different geographical origin and sera from rats immunized with R0.10C Alum and Alum/GLA formulation

From: Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants

Group

Rat

NF54

NF135

Inf

Mean (SD)

TRA, %

Inf

Mean (SD)

TRA, %

Alum

1

16

7.35 (6.23)

82

17

6.60 (5.99)

76

 

2

17

4.45 (4.00)

89

6

0.60 (1.14)

98

 

3

1

0.05 (0.22)

100

0

0.0 (0.0)

100

 

4

16

4.30 (4.71)

89

10

0.90 (1.21)

97

 

5

17

3.20 (2.86)

92

4

0.39 (0.78)

99

Alum/GLA

6

18

27.7 (14.7)

31

17

7.70 (6.87)

72

 

7

19

38.8 (23.3)

3

20

15.4 (9.2)

45

 

8

20

41.7 (25.9)

0

18

27.1 (15.2)

3

 

9

20

17.8 (8.1)

55

18

10.0 (5.85)

64

Pre sera

 

35/35

39.9 (23.6)

0

40/40

27.8 (12.6)

0

  1. Day 42 sera (1:27 diluted) were tested in the SMFA. Seven days after membrane feed, the number of infected mosquitoes and oocyst density were determined. Sera: rat serum from R0.10C-immunized group; Control: feeder with pooled pre-bleed serum (day 0) of the group. Inf: total infected from 20 dissected mosquitoes; SD: Standard deviation; TRA, %: percentage of Transmission Reducing Activity. NF54: African strain and NF153: Cambodian strain