Table 6 Mean pharmacokinetic parameters following 3 day oral administration of arterolane maleate and piperaquine phosphate
Analyte | Parameters | Cmax (ng/mL) | AUClast (ng h/mL) | AUC48-72 (ng h/mL) | t1/2 (h) |
|---|---|---|---|---|---|
n | 50 | 50 | 48 | 26 | |
Arterolane maleate | AM | 90.68 | 1507.93 | 688.29 | 3.30 |
Median | 83.65 | 1209.30 | 615.25 | 3.24 | |
Minimum | 23.38 | 110.74 | 137.71 | 2.04 | |
Maximum | 204.96 | 6174.14 | 1696.75 | 5.48 |
| Â | n | 50 | 50 | 48 | 48 |
|---|---|---|---|---|---|
Piperaquine phosphate | AM | 578.97 | 58,472.41 | 7333.04 | 292.72 |
Median | 497.77 | 50,453.06 | 6417.42 | 221.48 | |
Minimum | 58.71 | 965.76 | 2337.00 | 94.60 | |
Maximum | 1604.18 | 169,956.99 | 20,590.96 | 801.86 |