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Fig. 4 | Malaria Journal

Fig. 4

From: Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case–control study of Ugandan children

Fig. 4

Haemopexin-deficient mice are more susceptible to experimental cerebral malaria. a Both haemopexin knockout (Hpx KO) and haemopexin heterozygous (Hpx HT) mice have decreased survival during ECM than their wild type (Hpx WT) littermates (pooled data from four biological replicates; n = 39–44/group; log rank test, *p < 0.05). All three genotypes had similar levels of b parasitaemia (representative data from a single experiment; n = 7–12/group). The Hpx KO animals had significantly higher levels of c plasma haemin on day 7 post infection, Mann–Whitney, **p < 0.01. The dotted line indicates upper limit of detection for the assay (8.4 uM). The plasma levels of d haemopexin, and e haptoglobin throughout the course of infection (n = 4/group); two-way ANOVA, d p = 0.0018, e p = 0.0002. Samples were collected on day 0 and day 7 post infection, then at cardiac puncture (CP) when mice were moribund

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