Table 4 In vivo antiplasmodial efficacy of compounds 1 in C57BL/6 mice blood infected with P. berghei
Test group | Average % parasitemia | % reduction of parasitemia | ||
|---|---|---|---|---|
Day 4 | Day 6 | Day 9 | Day 9 | |
Oral (20 mg/kg/day) | 5.3 ± 3.9 | 22.7 ± 10 | 24.2 ± 5.6 | 3.7 ± 5.6 |
Oral (40 mg/kg/day) | 5.9 ± 2 | 10.7 ± 5 | 48.6 ± 12 | −93.8 ± 49.3 |
IV (4 mg/kg/day) | 0.4 ± 0.4 | 1.8 ± 1.4 | 8.1 ± 5 | 61.9 ± 26 |
IV (8 mg/kg/day) | 0 | 0.9 ± 0.9 | 5.1 ± 1.7 | 82.9 ± 2.5 |
Oral CQ (10 mg/kg/day) | 0 | 0 | 2 ± 1.6 | 92.0 ± 0.4 |
Placebo | 2.5 ± 2.4 | 7.3 ± 2.4 | 25.1 ± 0.4 | – |