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Fig. 3 | Malaria Journal

Fig. 3

From: Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases

Fig. 3

Additional functionalities and domains in Plasmodium falciparum aaRSs. Plasmodium falciparum TyrRS (shown as yellow rhombus) contain the ELR motif that helps it act as a cytokine to modulate immune functioning. Pf TyrRS is secreted during schizont burst from the infected red blood cells into blood stream. Released TyrRS interacts with dendritic cells and macrophages and gets internalized. This triggers release of TNF and IL6 and consequently results in increased host endothelium cell ICAM and VCAM expression. Lower panel shows aaRSs containing additional domain. N-terminal AlaX domain is present in the TrpRS and required for tRNA binding. β subunit of cytoplasmic PheRS contains a DNA binding domain B5. Cytoplasmic ProRS contain homologue of trans-editing factor Ybak fused to its N-terminal. AA, RBD and B3/B4 represent the aminoacylation domain, tRNA anticodon binding domain and the editing domain, respectively

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