Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats

Table 1 Influence of asiatic acid (10 mg/kg) on biophysical properties compared to controls

Parameter	Protocol name		Pre-patent (D 3)	Patent/ Treatment (D7–12)	Post-treatment (D 21)
Parameter		Animal Groups	Pre-patent (D 3)	Patent/ Treatment (D7–12)	Post-treatment (D 21)
Food intake (g/100 g)	Pre-infection per oral AA administration	NIC	10 ± 3	11 ± 2	12 ± 1
		IC	9 ± 1	6 ± 2	N/A
		30 CHQ	10 ± 1	6 ± 1	8 ± 4
		AA (10 mg/kg)	10 ± 3	9 ± 2^, *	12 ± 1**
Water intake (mL/100 g/day)	Pre-infection per oral AA administration	NIC	15 ± 3	13 ± 1	16 ± 2
		IC	15 ± 2	7 ± 2	N/A
		CHQ	14 ± 1	10 ± 1	12 ± 2γ
		AA (10 mg/kg)	15 ± 3	14 ± 1^, *	15 ± 2**
% body weight change	Pre-infection per oral AA administration	NIC	8 ± 3	10 ± 2	15 ± 1
		IC	8 ± 2	−4 ± 2	N/A
		CHQ	8 ± 1	5 ± 1γ	6 ± 1γ
		AA (10 mg/kg)	8 ± 4	11 ± 2^, *	14 ± 1**

Changes on percentage body weight gain, food and water intake of P. berghei- infected treated and non-treated animals were monitored. Values are presented as mean ± SEM, (n = 6 per group)
NIC non infected treated control, IC infected non-treated control, 30CHQ chloroquine 30 mg/kg.
*^, ** p < 0.05 by comparison to the IC, CHQ, respectively

ISSN: 1475-2875