Skip to main content

Table 1 McNemar’s χ2 test of haplotype proportions from pre- and post-treatment parasite pairs

From: Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

 

Pre- and post-treatment

Pre

Post

McNemar’s χ2 (p value)

OR (95 % CI)

AMA1

 

DQRHFDKY

Other

  

DQRHFDKY

0

0

  

Other

2

8

2 (0.16)

ND

EBA140

 

VSTK

Other

  

VSTK

5

2

  

Other

3

5

0.2 (0.65)

0.9 (0.5–1.6)

EBA181

 

Q

K

  

Q

5

4

  

K

2

2

0.67 (0.41)

1.3 (0.7–2.4)

EBA175

 

EKEKPISENKKK

Other

  

EKEKPISENKKK

    

Other

No data

   

EBL-1

 

QFFFF.VN

Other

  

QFFFF.VN

    

Other

No data

   

MSP1

 

KD

Other

  

KD

7

2

  

Other

5

3

1.29 (0.26)

0.8 (0.5–1.2)

MSP3

 

K1

3D7

  

K1

4

2

  

3D7

3

0

0.2 (0.65) 

0.9 (0.4–1.7) 

MSP6

 

K1

3D7

  

K1

1

2

  

3D7

3

9

0.2 (0.65)

0.8 (0.2–2.7)

MSPDBL1

 

ALTAIKY

Other

  

ALTAIKY

    

Other

No data

   

MSPDBL2

 

AHQAIRY

Other

  

AHQAIRY

2

6

  

Other

7

3

0.08 (0.78)

0.9 (0.4–2.0)

Rh1

 

4HN2QN

Other

  

4HN2QN

1

2

  

Other

1

3

0.33 (0.56)

1.5 (0.4–6.0)

Rh2b

 

156insQ585del

Other

  

156insQ585del

    

Other

No data

   

Rh5

 

HD

YH

  

HD

13

4

  

YH

0

3

4 (0.046)

1.3 (1.0–1.7)

  1. italic value indicates a significant increase in the odds of the Rh5 haplotypes changing compared to staying the same between parasite pairs before and after treatment
  2. Other represents genes with more than 2 high frequency haplotypes, the dominant allele was compared to all other alleles in the population, ND not determined, No data insufficient pairs for the analysis <4