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Table 1 Anti-malarial activity (% activity and EC50, μg/mL) of AHTS fractions from Berberis thunbergii (extract code 80679)

From: Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

Fraction or COMBI

Primary (% activity)

Secondary (EC50, μg/mL)

μg/mL

MAR3D7a

MARK1b

HEK293c

BJd

MAR3D7a

MARK1b

f8/c9

23.68

43.4

37

2.15

−0.85

  

f9/c8

35.75

95.2

80.2

2.52

6.63

8.15

7.57

f10/c7

23.68

97.4

95

8.13

4.91

0.53

0.63

f11/c6

14.39

96.9

96.5

5.29

0

2.02

3.6

f12/c5

8.37

92.8

93.4

7.42

0.7

0.61

0.81

f13/c5

5.57

92

92.4

3.59

0.45

0.39

0.45

f14/c4

5.11

89.9

96

5.05

−0.48

0.86

2.07

f15/c4

7.43

84.9

97.6

6.94

0.56

1.11

10.61

f16/c3

11.14

84.4

93.7

10.1

1.13

0.21

4.77

f17/c2

6.96

95.7

94.6

1.09

1.48

1.66

1.7

f18/c2

5.11

76.9

39

3.12

−0.94

  

f19/c1

4.18

35.6

21.2

1.29

0.64

  
  1. aChloroquine-sensitive P. falciparum strain
  2. bChloroquine-sensitive P. falciparum strain
  3. cHuman embryonic kidney cells
  4. dHuman foreskin fibroblast