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Table 2 Anti-malarial activity of compounds 1 and 9–13 and fractions from Berberis thunbergii and Eugenia rigida against P. falciparum

From: Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

Sample

Unit

P. falciparum EC50

Sample

P. falciparum EC50

3D7

K1

3D7

K1

BT-EtOHa

μg/mL

NTg

NT

ER-EtOHh

>100

>100

BT-P-Ab

μg/mL

0.25

0.291

ER-MeOHi

2

1.37

BT-P-Bc

μg/mL

0.23

0.19

ER-Hexj

>100

>100

BT-P–Cd

μg/mL

NT

NT

ER-Hex-33-52k

1

0.6

BT-P-De

μg/mL

10

10

ER-Hex-53-60l

0.7

0.6

7 + 8 f

μg/mL

100

0.42

ER-EtOAcm

>100

>100

1

μM

0.46

0.44

11

7.7

4.0

9

μM

0.035

0.15

12

NT

NT

10

μM

NT

NT

13

0.3

1.1

  1. a BT-EtOH EtOH extract of B. thunbergii
  2. b BT-P-A acidic CHCl3 fraction of BT
  3. c BT-P-B basic CHCl3 fraction of BT
  4. d BT-P-C EtOAc fraction of BT
  5. e BT-P-D aqueous fraction of BT
  6. fMixture of 7 and 8
  7. g NT not tested
  8. h ER-EtOH EtOH extract of E. rigida
  9. i ER-MeOH MeOH extract of ER
  10. j ER-Hex n-hexane extract of ER
  11. k ER-Hex-33-52 RP-CPTLC fraction of ER
  12. l ER-Hex-53-60 RP-CPTLC fraction ER
  13. m ER-EtOAc EtOAc extract of E. rigida