Fig. 2

Potentiation of anti-plasmodial activity of artemisinin derivatives by Cys in Plasmodium chabaudi AS blood-stage infection (in vivo assays). Groups of A/J mice (minimum of 5 mice per group) were infected with P. chabaudi pRBCs, and were treated with different drug regimens at the indicated doses (in mg/kg). Cys dose was fixed at 140 mg/kg in panels a, b, and d, and at variable doses (20, 40, 60, 80, 100 mg/kg) in panel c. Artemisinin derivatives tested were ART (a), ARTM (b, c), and ARTE (d). The intensity of infection (blood parasitaemia) was measured at day 5 post-infection and is shown as whisker plots (interquartile ranges; mean, with minimum to maximum). The inhibitory activity of different drug treatments is shown as a fraction (% inhibition) of parasitaemia detected in control mice treated with PBS. Statistical significance was calculated by unpaired student t test, *p < 0.05. The data is representative of three independent experiments