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Fig. 5 | Malaria Journal

Fig. 5

From: Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

Fig. 5

Potentiation of anti-plasmodial activity of ART by Cys in Plasmodium berghei cerebral malaria (ex vivo/in vivo assay). P. berghei pRBCs were exposed to different drug combinations (indicated in micromolar, µM) in vitro for 1 h at 37 °C (see Fig. 1). They were then washed free of drugs and used to infect naïve mice. Groups of C57BL/6J (B6) mice (minimum of 5 mice per group) were infected with 105 drug-treated P. berghei ANKA-pRBCs, and monitored for blood parasitaemia (a, c, e) at the indicated times post-infection, and mortality was recorded (b, d). The potentiation of ART by decreasing concentrations of Cys, 50 micromolar (a, b), 25 micromolar (c, d), 15 and 5 micromolar (e) was tested. Mortality on panels a, c, e is indicated by a cross. Data is expressed as mean ± SD for each group (*p < 0.05). The data is representative of three independent experiments

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