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Table 3 Distribution of different pvdhfr and pvdhps combination haplotype Kolkata and Purulia

From: Low prevalence of dihydro folate reductase (dhfr) and dihydropteroate synthase (dhps) quadruple and quintuple mutant alleles associated with SP resistance in Plasmodium vivax isolates of West Bengal, India

Genotype

Isolates in KMC

Isolates in P

PVDHFR

PVDHPS

Allele type

15

33

50

57

58

61

64

117

173

373

380

382

383

384

512

553

585

601

G1

11

17

A

P

N

F

S

T

V

S

I

S

E

S

A

P

K

A

V

M

Wild

G2

3

1

A

P

N

F

R

T

V

S

I

S

E

S

A

P

K

A

V

M

SM

G3

6

6

A

P

N

F

R

T

V

N

I

S

E

S

A

P

K

A

V

M

DM

G4

0

4

A

P

N

F

S

T

V

N

I

S

E

S

A

P

K

A

V

M

SM

G5

8

3

A

P

N

F

S

T

V

S

I

S

E

S

G

P

K

A

V

M

SM

G6

15

7

A

P

N

F

R

T

V

N

I

S

E

S

G

P

K

A

V

M

TM

G7

7

0

A

P

N

F

R

T

V

N

I

S

E

S

G

P

K

G

V

M

QM

G8

0

6

A

P

N

F

R

T

V

S

I

S

E

S

A

P

K

G

V

M

DM

G9

0

3

A

P

N

F

S

T

V

S

I

S

E

S

A

L

K

A

V

M

SM

G10

2

0

A

P

N

L

R

T

V

N

I

S

E

S

G

P

K

G

V

M

QTM

  1. Bold amino acids are the mutant codon
  2. SM, DM, TM, QM and QTM are respectively denote as single mutant, double mutant, triple mutant, quadruple mutant and quintuple mutant allele
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Malaria Journal

ISSN: 1475-2875

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