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Fig. 5 | Malaria Journal

Fig. 5

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Fig. 5

Pharmacokinetic-pharmacodynamic correlation. The best three PK-iPD correlations are shown in (a, b). All the PK parameters following IV AS treatment: t1/2 of AS + DHA (r2 0.772), the Vz of AS (r2 0.724), and AUC0–∞ of DHA (r2 0.709) showed strong and significant (p ≤ 0.002) correlation with the parasite clearance half-life (PCt1/2). The ePD-iPD correlation following both treatments is shown in (c). The PCt1/2 significantly (p ≤ 0.04) and inversely correlated well with the Cmax of the effect kinetics following IV AL (r2 0.615) and correlated with the clearance (Cl) of the effect kinetics following IV AS (r2 0.570). Solid line denotes linear regression and dotted line denotes 95 % confidence interval

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