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Table 4 Correlation between PK and ePD

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

PK-ePD linear regression

IV AL

IV AS

Parameter

Analyte

a

b

r2

p

a

b

rp

p

Cmax (mM)

Parent

    

1.04

7.45

0.807

<0.001

t1/2 (min)

Parent

0.69

7.89

0.964

<0.001

    

Metabolite

    

0.72

9.09

0.743

0.001

AUC0–∞ (mM min)

Parent

7.88

124

0.951

<0.001

    

Combined

    

1.12

265

0.847

<0.001

AUC0–20 (mM min)

Parent

8.09

32.7

0.751

0.005

0.94

76.3

0.803

<0.001

  1. PK = a*ePD + b