Skip to main content

Table 3 IgG Titres to the immunising antigen at specified time points

From: Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

Day

PfAMA1

Tetanus toxoid

IgG (95 % CI)

N

IgG (95 % CI)

N

Panel A. IgG titres to AMA1 FVO

0

5164 (2494–10,691)

20

9938 (4484–22,025)

20

28

13,888 (7017–27,484)

20

10,475 (4892–22,428)

20

56

14,954 (7923–28,222)

20

9192 (4103–20,591)

19

84

17,584 (9889–31,267)

19

8744 (4184–18,276)

18

140

14,048 (7808–25,275)

20

12,793 (7187–22,773)

20

364

6925 (3295–14,555)

19

6551 (2896–14,818)

16

Panel B. Titre changes following vaccination (fold increase)

0

1

20

1

20

28

2.69 (1.73–4.18)

20

1.05 (0.87–1.28)

20

56

2.90 (1.87–4.48)

20

0.93 (0.70–1.25)

19

84

3.53 (2.30–5.42)

19

1.07 (0.72–1.58)

18

140

2.72 (1.88–3.94)

20

1.29 (0.86–1.93)

20

364

1.46 (1.02–2.09)

19

0.89 (0.61–1.28)

16