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Fig. 1 | Malaria Journal

Fig. 1

From: Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Fig. 1

Retention of Plasmodium falciparum ring-infected RBCs. a Mean retention rate (± SEM) of P. falciparum (FUP line) ring-infected HbAA (n = 16), HbAS (n = 26) and HbSS (n = 4) RBCs in microsphilters under normoxic conditions. b Mean retention rate (± SEM) of P. falciparum (FUP line) ring-infected HbAA (n = 4) and HbAS (n = 8) RBCs in microsphilters exposed to ‘moderate’ hypoxia (1 % O2, 3 % CO2, 96 % N2 for 15 min). c Median retention rate (interquartile range, range) of ring-infected RBCs obtained directly from Malian HbAA (n = 29) and HbAS (n = 8) children with P. falciparum malaria and passed through microsphilters under normoxic conditions. d Mean retention rates (± SEM) of ring-infected HbAA (n = 6) and HbAS RBCs (n = 6) passed through microsphilters under normoxic conditions. These samples were prepared by obtaining P. falciparum isolates from Malian children with malaria, cultivating them to the schizont stage, purifying and inoculating them into fresh HbAA and HbAS RBCs simultaneously, and cultivating them to the ring stage in parallel

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