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Fig. 6 | Malaria Journal

Fig. 6

From: Probucol dramatically enhances dihydroartemisinin effect in murine malaria

Fig. 6

Effect of combination of DHA and probucol on Plasmodium yoelii XL-17 infection in mice. Probucol only group (Pro, n = 8) and probucol and DHA combination group (Pro + DHA, n = 8) were fed with 0.25 % (w/w) probucol mixed diet from 2 weeks before infection to throughout infection period. DHA group (DHA, n = 8) and Pro + DHA group were treated with 7.5 mg/kg of DHA by intraperitoneal injection on 3–5 days post infection once a day. Plasmodium yoelii XL-17 (4 × 104 iRBC/head) were inoculated in mice by intraperitoneal injection. Solvent was injected to mice as control (n = 7). Survival rate (a), parasitaemia (b) and haemoglobin concentration (c) were monitored. The data are mean ± SD. Treated group compared with Solvent group: *p < 0.05, **p < 0.01. Single treatment groups compared with Pro + DHA group: # p < 0.05, ## p < 0.01

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