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Table 1 Inhibitory activity of hexane bark extract of Z. heitzii and pure compounds isolated from the extract against P. falciparum in 72 h assays

From: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite

 

IC50

IC50

(μg/ml)

(µM)

Hexane bark extract

0.050 ± 0.004

N/A

Dihydronitidine

0.0089 ± 0.0008

0.025 ± 0.002

Pellitorine

1.96 ± 0.12

8.8 ± 0.5

Heitziquinone

3.55 ± 0.62

9.7 ± 1.6

Sesamin

>10

>28

Isobauerenol

>10

>23

Caryophyllene oxide

>10

>49

Rhoifoline B

>10

>28

Isoarnottianamide

>10

>26

Nitidinea

0.038 ± 0.002

0.099 ± 0.050

WR 99210a

3.167 × 10−6

1.2 × 10−5

  1. Results ± SEM from three biological replicates using 3D7 parasites are shown
  2. aPositive control