Table 4 Polymorphism in partial sequences of DHFR-TS from P. ovale and P. malariae isolates in the China–Myanmar border area

P. falciparum

A16

C50

N51

M55

K56

Y57

F58

C59

A60

T62

T63

S108

L131

K155

F162

I164

Y226

K341

3D7 Reference

P. falciparum

V

R

I

–

–

–

–

R

–

–

–

N/T

–

–

–

L

–

–

Mutant type [51]

P. vivax

I13

C49

N50

M54

K55

Y56

F57

S58

S59

T61

T62

S117

L140

K164

F171

I173

Y235

K357

Pv_Sal-1

P. vivax

L

–

–

–

–

–

L/T

R

–

M

–

N

–

–

–

L

–

–

Mutant type [51]

Po. curtisi

A15

Y49

N50

I54

S55

Y56

F57

S58

S59

T61

T62

S113

L136

K160

F167

I169

Y231

K370

KP050405 [52]

Po. curtisi

S

–

–

–

–

–

–

R

–

–

–

–

–

–

–

–

–

–

KP050408 [52]

Po. wallikeri

A15

C49

N50

I54

S55

Y56

F57

S58

S59

T61

T62

S113

L136

K160

F167

I169

Y231

K374

KP050406 [52] ]

Po. wallikeri

–

–

–

–

–

C

–

–

–

–

–

–

–

–

–

–

–

–

EU266605 [12]

Po. wallikeri

–

–

–

–

–

–

L

–

–

–

–

–

–

–

–

–

–

–

KP050409 [52]

C0100511

Y

N

I

S

Y

F

S

S

T

T

S

L

K

F

I

Y

K

China (KX672038)

M0102751

–

–

–

–

–

–

–

–

–

A

C

–

–

–

–

H

E

Myanmar (KX672039)

M0500214

–

–

–

–

–

–

–

–

–

T

C

–

–

–

–

Y

K

Myanmar (KX672037)

P. malariae

A15

S49

N50

M54

K55

Y56

F57

S58

S59

T61

T62

S114

L137

K161

F168

I170

F232

K355

EF188271, Pm3 [44]

P. malariae

–

–

K

–

E

–

–

R

A

–

–

N/G

–

S

S

M

–

–

Mutant type [44, 51]

C0400117

S

N

M

K

Y

F

S

S

T

T

S

L

K

F

I

F

K

China (KX672042)

M0N00290

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

Myanmar (KX672043)

M0N00556

A

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

Myanmar (KX672041)

M0N00648

A

–

–

–

–

–

–

–

–

–

–

–

P

R

–

–

–

–

Myanmar (KX672040)