Table 3 Prevalence of amino acid substitutions in the putative drug-resistance related genes in Plasmodium falciparum isolates collected before artemether–lumefantrine treatment
From: Absence of in vivo selection for K13 mutations after artemether–lumefantrine treatment in Uganda
Gene | Amino acid position | Genotypes | ||
|---|---|---|---|---|
Wild type (n, %) | Mutant (n, %) | Mixed (n, %) | ||
Pfkelch13 | 141 (98.6) | 2 (1.4) A578S | 0 | |
fd | D193Y | 127 (100) | 0 | 0 |
mdr2 | T484I | 126 (100) | 0 | 0 |
arps10 | V127M | 127 (100) | 0 | 0 |
pph | V1157 | 122 (100) | 0 | 0 |
pibp | C1484F | 127 (100) | 0 | 0 |
Pfcrt | K76T | 98 (68.1) | 42 (29.2) | 4 (2.7) |
I356T | 122 (97.6) | 0 | 3 (2.4) | |
Pfmdr1 | N86Y | 141 (98.0) | 3 (2.1) | 0 |
Y184F | 115 (80.4) | 14 (9.8) | 14 (9.8) | |
S1034C | 143 (98.6) | 2 (1.4) | 0 | |
N1042D | 145 (100) | 0 | 0 | |
D1246Y | 134 (93.7) | 9 (6.0) | 0 | |