Mutation allele | Total (N = 101) | IPTp-SP− (n = 52) | IPTp-SP+ (n = 49) | Crude OR 95% CI | P value |
---|---|---|---|---|---|
Pfdhfr N51I | 0.003 | ||||
No | 29 (28.7) | 8 (15.4) | 21 (42.9) | 1 | |
Yes | 72 (71.3) | 44 (84.6) | 28 (57.1) | 0.24 (0.09–0.62) | |
Pfdhfr C59R | |||||
No | 58 (57.4) | 37 (71.2) | 21 (42.9) | 1 | 0.005 |
Yes | 43 (42.6) | 15 (28.9) | 28 (57.1) | 3.29 (1.44–7.50) | |
Pfdhfr S108N | |||||
No | 36 (35.6) | 22 (42.3) | 14 (28.6) | 1 | 0.1 |
Yes | 65 (64.4) | 30 (57.7) | 35 (71.4) | 1.83 (0.80–4.20) | |
Pfdhps A437G | |||||
No | 20 (19.8) | 11 (21.2) | 9 (18.4) | 1 | 0.7 |
Yes | 81 (80.2) | 41 (78.8) | 40 (81.6) | 1.19 (0.45–3.19) | |
Pfdhfr double mutation | 0.7 | ||||
No | 60 (59.4) | 30 (57.7) | 30 (61.2) | 1 | |
Yes | 41 (40.6) | 22 (42.3) | 19 (38.8) | 0.86 (0.40–1.91) | |
Pfdhfr triple mutation | 0.1 | ||||
No | 75 (74.3) | 42 (80.8) | 33 (67.4) | 1 | |
Yes | 26 (25.7) | 10 (19.2) | 16 (32.6) | 2.04 (0.82–5.07) | |
≥2 Pfdhfr mutation | 0.3 | ||||
No | 34 (33.7) | 20 (38.5) | 14 (28.6) | 1 | |
Yes | 67 (66.3) | 32 (61.5) | 35 (71.4) | 1.56 (0.69–3.60) |