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Table 3 Prevalence of Pfdhps and Pfdhfr mutations in isolates collected in three health facilities in Hodh Elgharbi region, Mauritania in 2010

From: Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

Gene Codon Aa n (%)
Aioun Kobeni Tintane Total
Pfdhps S436A/F S 17 (32) 33 (26) 32 (38) 82 (31)
S/A 10 (19) 16 (13) 10 (12) 36 (14)
A 26 (49) 75 (60) 43 (51) 144 (55)
F 0 2 (2) 0 2 (1)
A437G A 33 (62) 96 (76) 43 (51) 172 (65)
A/G 10 (19) 12 (10) 9 (11) 31 (12)
G 10 (19) 18 (14) 32 (38) 60 (23)
K540E/A K 52 (98) 122 (97) 85 (100) 259 (98)
K/A 0 1 (0.8) 0 1 (0.4)
K/E 0 2 (2) 0 2 (1)
E 1 (2) 1 (1) 0 2 (1)
Pfdhfr N51I N 31 (58) 73 (55) 39 (47) 143 (53)
N/I 10 (19) 16 (12) 11 (13) 37 (14)
I 12 (23) 44 (33) 33 (40) 89 (33)
C59R C 32 (60) 68 (51) 40 (48) 140 (52)
C/R 9 (17) 18 (14) 9 (11) 36 (13)
R 12 (23) 47 (35) 34 (41) 93 (35)
S108N/T S 31 (58) 68 (52) 42 (51) 141 (53)
S/T 1 (2) 3 (2) 1 (1) 5 (2)
S/N 7 (13) 14 (11) 6 (7) 27 (10)
T/N 2 (4) 1 (1) 6 (7) 9 (3)
T 2 (4) 0 1 (1) 3 (1)
N 10 (19) 46 (35) 27 (33) 83 (31)
I164L I 52 (98) 131 (99) 73 (88) 256 (96)
I/L 1 (2) 1 (1) 10 (12) 12 (4)
  1. aa amino acid, n number of isolates. All isolates had the wild-type Pfdhps alleles in codons 581 and 613. Mutant alleles are denoted in bold characters