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Fig. 4 | Malaria Journal

Fig. 4

From: New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission

Fig. 4

Pfs25 epitope specific vectors design. a Amino acid sequence of Pfs25. The selected Pfs25 EGF domains II and III from which the epitope peptides (denoted as D2 and D3) were chosen for HVR insertion are indicated in green and orange, respectively. b Predicted Pfs25 structure based on the structure of the P. vivax homolog, Pvs25. The D2 and D3 epitopes in EGF domains II and III, respectively, are highlighted in red. c Ad5 Hexon capsid protein structure. Ad5 Hexon trimer structure (Protein Data Bank 1P30) with the modelled HVRs highlighted (HVR1, red; HVR2, green; HVR3, pink; HVR4, light blue; HVR5, yellow; HVR6, blue; HVR7, cyan). d yPfs25-specific antibody titer. Mice (n = 3 per group) were immunized with 1010 viral particles of Ad5 displaying the D2 or D3 Pfs25 peptide epitope within HVR5 (denoted Ad5-HVR5D2 or Ad5-HVR5D3, respectively) or PBS control and yPfs25-specific ELISA was performed and data depict endpoint dilutions for 3 individual animals where error bars depict standard deviation

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