Fig. 2From: Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challengesDeterminants of in vivo response to anti-malarial treatment. a The process by which infected erythrocytes containing mature parasites adhere to the microvasculature. Their removal of from the circulation results in the peripheral parasite count being an underestimate of the true parasite biomass. b The developmental stage of the parasite. The artemisinin compounds have the broadest stage specific action against the parasite. c Simultaneous rupture of hepatic schizonts result in a uniform stage distribution of the parasiteBack to article page