PK parametera (unit) | 800 mg KAF156 + 1280 mg PPQ N = 23 (mean, SD, CV%) | 1280 mg PPQ N = 24 (mean, SD, CV%) |
---|---|---|
Cmax (ng/mL) | 409 ± 299 (73.2%) [n = 23] | 233 ± 169 (72.3%) [n = 24] |
AUClast (h µg/mL) | 10.8 ± 6.14 (56.8%) [n = 22] | 10.3 ± 4.16 (40.2%) [n = 23] |
AUCinf (h µg/mL) | 11.9 ± 5.25 (44.1%) [n = 19] | 12.0 ± 5.31 (44.2%) [n = 17] |
AUC0-24 h (h µg/mL) | 2.94 ± 1.81 (61.5%) [n = 22] | 2.09 ± 0.993 (47.4%) [n = 24] |
AUC0-72 h (h µg/mL) | 4.73 ± 2.89 (61.0%) [n = 22] | 3.49 ± 1.56 (44.8%) [n = 24] |
AUC0-168 h (h µg/mL) | 6.35 ± 3.67 (57.9%) [n = 21] | 4.82 ± 1.95 (40.4%) [n = 23] |
Tmax (h) | 3.00 (2.00–4.05) [n = 23] | 4.00 (3.00–8.00) [n = 24] |
T1/2 (h) | 469 ± 170 (36.2%) [n = 19] | 509 ± 142 (27.9%) [n = 17] |
CL/F (mL/h) | 127,000 ± 53,100 (41.7%) [n = 19] | 126,000 ± 52,700 (41.9%) [n = 17] |
Vz/F (L) | 82,200 ± 34,500 (42.0%) [n = 19] | 89,100 ± 32,800 (36.8%) [n = 17] |