Fig. 4
Effect of iron supplementation on Plasmodium chabaudi infection. Clinical course in P. chabaudi AS-infected (1 × 104 IEs i.p.), iron-replete (black circle red line) or iron-deficient mice (white circle blue line, white diamond purple line, white triangle green line, white square grey line), treated on Day −4 to Day −2 before infection only (white diamond purple line) or on Day 7 to Day 9 post-infection only (black circle red line, white circle blue line, white diamond purple line, white triangle green line) with carboxymaltose i.p. (black circle red line, white circle blue line), ferric carboxymaltose i.p. (white diamond purple line, white triangle green line), or ferrous sulfate p.o. (white square grey line). Panels depict a survival, b temperature, c parasitaemia, d weight change, e haemoglobin, and f reticulocyte fraction. Initial group sizes, group means (symbols) and SD (error bars; b–f) are indicated