Identifying risk factors for the development of sepsis during adult severe malaria

Malaria Journal

Table 2 Univariable analysis of predictors for the development of sepsis in patients admitted for severe malaria

	Characteristic	Category	N	OR	95% CI	p value
1	Age	Age (years)	1187	1.00	0.98, 1.01	0.749
2	Sex	Sex^a
		Female	288	0.37	0.24, 0.58	< 0.001
		Male	899	1.00
3	Cerebral malaria	Coma (GCS < 11 or BCS < 3)
		Yes	476	1.47	0.95, 2.28	0.088
		No	711	1.00
		Convulsions
		Yes	113	1.28	0.64, 2.54	0.490
		No	1074	1.00
		Prostration^a
		Yes	435	0.61	0.37, 0.99	0.050
		No	752	1.00
4	Haemodynamic shock	Systolic BP (mm/Hg)^a,b	1177	0.98	0.97, 0.99	0.001
		Diastolic BP (mm/Hg)^a,b	1176	0.98	0.96, 0.99	0.002
		MAP (mm/Hg)	1176	0.98	0.96, 0.99	0.001
		Clinical shock^a
		Yes	137	2.74	1.62, 4.65	< 0.001
		No	1050	1.00
5	Severe anaemia	Haemoglobin (g/dl)^a	1112	0.94	0.87, 1.00	0.052
5	Severe anaemia	Haematocrit (%)	1100	0.98	0.96, 1.00	0.080
6	Renal failure	BUN level (mg/dl)^a	1127	1.01	1.01, 1.01	< 0.001
6	Renal failure	Serum potassium (mg/dl)	1076	1.23	0.94, 1.61	0.161
7	Jaundice	Jaundice^a
		Yes	624	1.85	1.17, 2.94	0.009
		No	563	1.00
8	Hypoglycaemia	Glycaemia (mg/dl)	1146	1.00	0.99, 1.00	0.438
9	Hyperpyrexia	Temperature (°C)	1185	0.96	0.79, 1.16	0.655
10	Acidosis	Venous pH^a,b	1068	0.09	0.02, 0.40	0.002
		Base excess (mmol/l)^a	1075	0.94	0.92, 0.97	<0.001
		Total CO ^a,b₂	1071	0.92	0.89, 0.96	< 0.001
		Anion gap (mmol/l)^a	1050	1.04	1.01, 1.06	0.002
11	Hyperparasitaemia	Parasite count (/μl)^a	1187	2.57	1.57, 4.19	< 0.001
11	Hyperparasitaemia	Percentage parasitaemia (%)^a,b	1187	1.04	1.02, 1.06	< 0.001
12	Respiratory distress	Respiratory rate (cycles/min)^a	1185	1.02	1.01, 1.05	0.003
		Respiratory distress^a
		Yes	117	3.14	1.82, 5.39	< 0.001
		No	1070	1.00

BCS Blantyre coma score, GCS Glasgow coma score, BP blood pressure, MAP mean arterial blood pressure, OR odds ratio, CI confidence interval, BUN blood urea nitrogen, mm/Hg millimetres of mercury, mmol/l millimoles per litre, g/dl grams per decilitre, mg/dl milligrams per decilitre, °C degrees centigrade; μl microlitre, min minute
^aSignificant variables on univariate analysis
^bVariables omitted from logistic regression model due to multicollinearity

ISSN: 1475-2875