Identifying risk factors for the development of sepsis during adult severe malaria

Malaria Journal

Table 3 Multivariable logistic regression and bootstrap analysis for predictors for development of sepsis in patients admitted for severe malaria

Predictors	Category	aOR	95% CI	p value	BOR	B 95% CI	B p value
Sex^*,b	Female	2.36	1.34, 4.17	0.003	2.36	1.30, 4.29	0.005
Sex^*,b	Male	1.00			1.00
Coma on admission^b	Yes	2.17	1.21, 3.90	0.010	2.17	1.19, 3.93	0.011
Coma on admission^b	No	1.00			1.00
Prostration on admission	Yes	1.00	0.55, 1.84	0.989	1.00	0.55, 1.84	0.989
Prostration on admission	No	1.00			1.00
Mean arterial pressure (mmHg)		0.99	0.97, 1.01	0.325	0.99	0.97, 1.01	0.308
Shock on admission^b	Yes	2.85	1.35, 5.99	0.006	2.85	1.29, 6.28	0.009
Shock on admission^b	No	1.00			1.00
Haemoglobin on admission (mg/dl)		0.98	0.90, 1.07	0.646	0.98	0.89, 1.08	0.687
BUN (mg/dl)^*,b		1.01	1.00, 1.02	0.004	1.01	1.00, 1.02	0.005
Visible jaundice on admission^b	Yes	1.78	1.03, 3.07	0.038	1.78	1.02, 3.10	0.042
Visible jaundice on admission^b	No	1.00			1.00
Base excess on admission (mmol/l)		1.01	0.97, 1.05	0.735	1.01	0.97, 1.05	0.742
Anion gap on admission^*,b		1.02	1.01, 1.05	0.043	1.02	1.00, 1.05	0.050
Percentage parasitaemia on admission (%)^b		1.03	1.01, 1.06	0.008	1.03	1.01, 1.06	0.014
Respiratory rate on admission (cycles/minute)		0.98	0.95, 1.02	0.344	0.98	0.95, 1.02	0.328
Respiratory distress on admission^b	Yes	3.62	1.69, 7.76	0.013	3.62	1.64, 8.02	0.002
Respiratory distress on admission^b	No	1.00			1.00
Somers’ D^a		0.52			0.49

aOR adjusted odds ratio, CI confidence interval, BUN blood urea nitrogen, BOR bootstrapped odds ratio, B bootstrapped, mmol/l millimoles per litre, mg/dl milligrams per decilitre
* Variables significant on multivariable analysis
^aEstimate of optimism = 0.03
^bIncluded in final regression model

ISSN: 1475-2875