Table 2 HS ELISA performance using Plasmodium falciparum positive and negative clinical specimens from Uganda and Myanmar that were (A) confirmed by composite microscopy and qRT-PCR and (B) confirmed by qRT-PCR and HRP2 concentrations below 400 pg/mL
Panel A | |||||
|---|---|---|---|---|---|
Microscopy and qRT-PCR | Sensitivity (95% CI) | Specificity (95% CI) | |||
Positive | Negative | ||||
HS ELISA | Positive | 100 | 4 | 100% (96.4–100%) | 97.9% (94.8–99.4%) |
Negative | 0 | 191 | |||
Panel B | |||||
|---|---|---|---|---|---|
qRT-PCR and HRP2 < 400 pg/mL | Sensitivity (95% CI) | Specificity (95% CI) | |||
Positive | Negative | ||||
HS ELISA | Positive | 30 | 3 | 100% (88.4–100%) | 88.9% (70.8–97.6%) |
Negative | 0 | 24 | |||