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Table 1 Neurologic toxicity of plasmocid in different animal species [1]

From: Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Species

Minimum lethal daily dose (mg/kg/day)/Minimum cumulative dose causing neurologic signs or lesions (mg/kg)a

Human equivalent doses based on body surface area (mg/kg)b

Rhesus monkeys

4.5/3

1.4/0.96

Cynomolgus monkeys

< 3/6

< 0.96/1.9

Sooty Mangabey monkeys

24/72

7.7/23

Dogs

3/9

1.7/5

Rats

24/196

3.9/32

Mice

72/144

5.9/12

  1. aDoses administered as three equal divided doses daily until animals succumbed or were sacrificed
  2. bCalculated according to FDA recommendations [21]