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Fig. 5 | Malaria Journal

Fig. 5

From: Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi

Fig. 5

Characterization of the infection in RFa14. a, c, f The experimentally obtained data for reticulocytes, RBCs, and infected RBCs with the corresponding model fits. a Also exhibits the result of an alternative model, in dark blue solid line, which is obtained for a reticulocyte-RBC preference ratio of 15:1 and fits the data better than the 477:1 ratio shown in lighter solid blue. b Time courses for the reticulocyte maturation time and erythropoietic output. d Time courses of the numbers of cells being lost due to the bystander effect and by parasitization. e Time courses of the numbers of cells being lost by senescent removal and random loss. f Experimental data for infected RBCs (green dots), model fit to the infected RBCs (green line), immune response time course (purple line), and sub-curative and curative treatment windows (pink boxes; the left side of the boxes depicts the experimental point-of-treatment, while the window width depicts the modelled time course of progressive cell removal, until the right side of the box is reached, where the model assumes that all infected RBCs have been killed by the treatment). Results of a second alternative model are shown in a, b, d as dotted lines. This alternative model fit is obtained assuming an exactly equal increase in RBC production and loss due to bystander effect between Days 33 and 35. Although unlikely, this hypothetical setting does lead to an increase in reticulocytes without any change in RBC numbers

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