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Fig. 7 | Malaria Journal

Fig. 7

From: Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi

Fig. 7

Comparison of the levels of RBC production and removal among ‘E04’ macaques. Total extent of RBC production and removal per macaque and for the average of RFa14, Rsb14 and RIc14 during the first 50 days of infection is shown. RMe14 was excluded from the average as this macaque received a blood transfusion that invalidates the true quantification of RBC production and removal. The extent of RBC production each macaque would have had if it had remained in its healthy state, shown during the first few days is highlighted with a lighter shade of green, out of the total measured RBC production. RBC removal is shown per process. The normal physiological processes are senescence and random loss. Infection-induced pathological processes are parasitism (invasion by the parasite) and bystander effect (loss of uninfected RBCs). Throughout the first 50 days of the infections, which include the primary parasitaemia peak but exclude relapses, 38 ±4% of RBCs were lost by the physiological processes (senescence and random loss), 38 ±6% due to bystander effect, and only 23 ±2% due to invasion by the parasite

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