Plant material (code)a | MLD50 (µg/ml)b | IC c50 (µg/ml) | Activity | ||
---|---|---|---|---|---|
BGM | HepG2 | PBMC | |||
Crude extracts | |||||
Stem bark (AP1) | ≥ 1000 | 410 ± 67 | ≥ 1000 | 3 ± 3 | AT |
Stem (AP4) | ≥ 1000 | 415 ± 17 | 404 ± 42 | 17 ± 4 | PA |
Root bark (AP9) | 287 ± 35 | 407 ± 60 | 492 ± 75 | 14 ± 1 | PA |
Roots (AP12) | ≥ 1000 | 415 ± 17 | 404 ± 42 | 18 ± 5 | PA |
Leaves | 486 ± 15 | 449 ± 49 | 548 ± 22 | 12 ± 4 | PA |
Fractions from AP1 | |||||
Organic (ethyl acetate) (AP3) | ≥ 1000 | 489 ± 13 | 435 ± 83 | 9 ± 3 | AT |
Aqueous (AP2) | ≥ 1000 | 636 ± 55 | ≥ 1000 | 20 ± 6 | PA |
Fractions from AP4 | |||||
Organic (ethyl acetate) (AP5) | ≥ 1000 | 316 ± 42 | 153 ± 13 | 6 ± 1 | AT |
Alkaloid-rich (AP5F.ALC) | ≥ 1000 | 418 ± 7 | 145 ± 17 | 5 ± 3 | AT |
Aqueous (AP5F.AQ) | ≥ 1000 | ≥ 1000 | ≥ 1000 | ≥ 50 | IN |
Butanolic (AP6) | ≥ 1000 | ≥ 1000 | ≥ 1000 | ≥ 40 | IN |
Aqueous (AP7) | ≥ 1000 | ≥ 1000 | ≥ 1000 | 27 ± 3 | IN |
Chloroquine | 457 ± 22 | 398 ± 12 | 150 ± 53 | 0.07 ± 0.02 | AT |