Levels of human proteins in plasma associated with acute paediatric malaria

Reuterswärd, Philippa; Bergström, Sofia; Orikiiriza, Judy; Lindquist, Elisabeth; Bergström, Sven; Andersson Svahn, Helene; Ayoglu, Burcu; Uhlén, Mathias; Wahlgren, Mats; Normark, Johan; Ribacke, Ulf; Nilsson, Peter

doi:10.1186/s12936-018-2576-y

Malaria Journal

Table 2 Proteins present in divergent levels in mild compared to severe malaria cases

From: Levels of human proteins in plasma associated with acute paediatric malaria

Primary biological process	Gene name	Uniprot ID	Gene description	p-value	Antibody
Cell migration and adhesion	ADAMTS13	Q76LX8	ADAM metallopeptidase with thrombospondin type 1 motif 13	2E−02	HPA042014
	CSF1	P09603	Colony stimulating factor 1	3E−02	HPA061864+
	IGFBP1	P08833	Insulin like growth factor binding protein 1	3E−02	MAB675 R&D
	ITGAV	P06756	Integrin subunit alpha V	2E−02	HPA004856
	VCAM1	P19320	Vascular cell adhesion molecule 1	2E−02	HPA069867+
	VWF	P04275	von Willebrand factor	4E−02	HPA002082
Erythrocyte associated	ANK1	P16157	Ankyrin 1	5E−02	HPA004842
	BPGM	P07738	Bisphosphoglycerate mutase	1E−02	HPA016493
	EPB41L2	O43491	Erythrocyte membrane protein band 4.1 like 2	3E−02	HPA005730
	GYPC	P04921	Glycophorin C (Gerbich blood group)	2E−02	HPA008965
	HBA1/2	P69905	Hemoglobin subunit alpha 1/2	1E−02	HPA043780
	MPP1	Q00013	Membrane palmitoylated protein 1	1E−02	HPA076675
Tissue remodelling	AGT	P01019	Angiotensinogen	3E−02	MAB3156 R&D
	CA2	P00918	Carbonic anhydrase 2	7E−03	HPA071085
	CALCA	P01258	Calcitonin related polypeptide alpha	4E−02	HPA064453
	ELANE	P08246	Neutrophil elastase	1E−02	MAB91671 R&D
	MMP2	P08253	Matrix metallopeptidase 2	2E−02	HPA001939
	MMP9	P14780	Matrix metallopeptidase 9	3E−02	HPA001238
Acute phase response	CD14	P08571	CD14 molecule	3E−02	HPA001887+
	CEBPA	P49715	CCAAT/enhancer binding protein alpha	3E−02	HPA052734
	CRP	P02741	C-reactive protein	3E−02	HPA027396
	LBP	P18428	Lipopolysaccharide binding protein	3E−02	HPA001508
	TNF	P01375	Tumour necrosis factor	5E−02	HPA077901+
Apoptosis	DAPK1	P53355	Death associated protein kinase 1	3E−02	HPA040472
	NGF	P01138	Nerve growth factor	5E−02	HPA063135
	RIPK2	O43353	Receptor interacting serine/threonine kinase 2	7E−03	HPA015764+
	TNFRSF1B	P20333	TNF receptor superfamily member 1B	2E−02	HPA004796
Axon associated	HAP1	P54257	Huntingtin associated protein 1	3E−02	HPA053019
Axon associated	NEFM	P07197	Neurofilament medium	3E−02	HPA022845
Motor protein	MYL3	P08590	Myosin light chain 3	3E−02	HPA016564
Motor protein	MYO15A	Q9UKN7	Myosin XVA	2E−02	HPA039770
T cell response	CD80	P33681	CD80 molecule	2E−02	HPA039851
T cell response	TNFSF13B	Q9Y275	TNF superfamily member 13b	4E−02	HPA030526
Cell cycle regulation	CDK14	O94921	Cyclin dependent kinase 14	3E−02	HPA015267
DNA replication	TIPIN	Q9BVW5	TIMELESS interacting protein	4E−02	HPA039704
Energy transduction	CKB/CKM	P12277, P06732	Creatine kinase B-type/M-type	4E−02	MAB5564 R&D

Information about the 37 proteins (number of UniProt IDs) showing differential levels between patients with severe and mild malaria. Proteins are grouped on primary biological function with displayed adjusted p-values based on the Wilcoxon rank-sum test. All these proteins showed higher levels in severe compared to mild malaria cases and include proteins, previously identified by us, as associated with severe malaria have been marked [21]. Proteins supported by multiple antibodies are marked + in the antibody column (see also Additional files 5, 11)

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ISSN: 1475-2875

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