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Table 3 Number of cases with each pfdhfr*/pfdhps** combined genotype* from different districts in Indonesia in two study periods

From: Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia

Year

Island

Province

District

n***

(mixed cases)

Pfdhfr/pfdhps combined genotypes

ANCSI*

ANCNI

ANRNI

SAKAA**

SGEAA

SAKAA

SGKGA

SAKAA

SGKAA

SGKGA

SGEAA

2004–2006

Sumatera

Riau

Indragiri Hilir

6

    

6

   

Kalimantan

East Kalimantan

Paser

25

      

1

4

   

(11)

       

(6a+3b)/2

Java

East Java

Pacitan

29

        

Lombok

West Nusa Tenggara

West Lombok

44

    

41

   
   

(1)

    

(1a)/2

  

(1a)/2

Sumbawa

West Nusa Tenggara

Sumbawa

77

1

 

5

 

43

8

 

6

   

(3)

(2a)/2

   

(1b)/2

(2a)/2

 

(1b)/2

Papua

Papua

Jayapura

9

       

9

   

190

1

 

5

 

90

8

1

19

   

(15)

(2)/2

   

(2)/2

(2)/2

 

(1)/2

Year

Island

Province

District

n***

(mixed cases)

Pfdhfr/pfdhps combined genotypes

ANRNI

ANRNL

SGEAA

(588F)

SGEGA

SGTGA

SGKAA

SGKGA

SGEAA

SGEGA

SGTGA

2004–2006

Sumatera

Riau

Indragiri Hilir

6

        

Kalimantan

East Kalimantan

Paser

25

  

15

    

5

   

(11)

 

(6a)/2

(3b+2c)/2

    

(2c)/2

Java

East Java

Pacitan

29

  

19

 

5

4

1

 

Lombok

West Nusa Tenggara

West Lombok

44

3

       
   

(1)

12

 

2

     

Sumbawa

West Nusa Tenggara

Sumbawa

77

        
   

(3)

        

Papua

Papua

Jayapura

9

        
   

190

15

 

36

 

5

4

1

5

   

(15)

 

(6)/2

(5)/2

    

(2)/2

Year

Island

Province

District

n***

(mixed cases)

Pfdhfr/pfdhps combined genotypes

ANCSI*

ANCNI

ANRNI

SAKAA**

SGEAA

SAKAA

SGKGA

SAKAA

SGKAA

SGKGA

SGEAA

2009–2012

Sumatera

Riau

Indragiri Hilir

1

     

1

  

Sumatera

Jambi

Merangin

1

        

Kalimantan

Middle Kalimantan

Seruyan

19

        

Kalimantan

South Kalimantan

Banjar

56

  

1

1

  

4

5

   

(3)

   

(1a)/2

  

(1b)/2

 

Lombok

West Nusa Tenggara

West Lombok

48

    

47

  

1

Timor

East Nusa Tenggara

Timor Tengah Selatan

3

    

3

   

Sulawesi

Gorontalo

Gorontalo

2

     

1

  

Papua

Papua

Jayapura

46

1

4

  

16

  

21

   

176

1

4

1

1

66

2

4

27

   

(3)

   

(1)/2

  

(1)/2

 

Year

Island

Province

District

n***

(mixed cases)

Pfdhfr/pfdhps combined genotypes

ANRNI

ANRNL

SGEAA

(588F)

SGEGA

SGTGA

SGKAA

SGKGA

SGEAA

SGEGA

SGTGA

2009–2012

Sumatera

Riau

Indragiri Hilir

1

        

Sumatera

Jambi

Merangin

1

      

1

 

Kalimantan

Middle Kalimantan

Seruyan

19

  

1

 

11

6

1

 

Kalimantan

South Kalimantan

Banjar

56

8

1

17

10

   

9

   

(3)

(1a+1b)/2

    

(1c)/2

 

(1c)/2

Lombok

West Nusa Tenggara

West Lombok

48

        

Timor

East Nusa Tenggara

Timor Tengah Selatan

3

        

Sulawesi

Gorontalo

Gorontalo

2

1

       

Papua

Papua

Jayapura

46

4

       
   

176

13

1

18

10

11

6

2

9

   

(3)

(2)/2

    

(1)/2

 

(1)/2

  1. pfdhfr genotype are presented with the amino acids at the position of 16, 51, 59, 108, 164, and ANCSI is the wild type of pfdhfr
  2. ** pfdhps genotype are presented with the amino acids at the position of 436, 437, 540, 581, 613 (and 588), and SAKAA is the wild type of pfdhps. The underlined letters indicate amino acid substitutions
  3. *** Number of mixed infection cases are presented in brackets as (N), and each pair of the mixed case is presented with superscript as (Na)/2