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Table 4 Prevalence of the parasites with pfdhfr/pfdhps quintuple and sextuple mutation in 2004–2006 and 2009–2012

From: Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia

Number of mutation*

2004–2006

2009–2012

P-value**

n

%

n

%

 

Kalimantan (n = 36)

Kalimantan (n = 78)

 

≥ 5

31

86.1

57

73.1

0.153

< 5

5

13.9

21

26.9

 
 

Lombok (n = 45)

Lombok (n = 48)

 

≥ 5

3

6.7

0

0

0.109

< 5

42

93.3

48

100

 
 

Papua (n = 9)

Papua (n = 46)

 

≥ 5

0

0

4

8.7

1

< 5

9

100

42

91.3

 
  1. * Quintuple, sextuple mutants are parasites containing five or six mutations in the pfdhfr/pfdhps combined haplotype. In this case, pfdhps 588F is included for counting number of mutation
  2. ** P-values were calculated by comparing actual number of patients presenting each genotype by Fisher’s Exact test