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Fig. 6 | Malaria Journal

Fig. 6

From: Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production

Fig. 6

Diagram showing the hypothesis of interaction between HZ and l-Arg. Free or macrophage-phagocytosed HZ may interact with l-Arg (HZ-l-Arg). Depending on the concentration of HZ, different amounts of l-Arg may be trapped, affecting NO production. At 25 µM, HZ does not remove all the l-Arg (iNOS substrate) and NO is produced by macrophages; at 100 µM, HZ removes almost all l-Arg impairing NO production

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