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Table 1 Comparison of rapid diagnostic test (RDTs) HRP2 (First Response®) and pLDH/HRP2 (Combo®) with microscopy

From: Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana

Tests results

GS: Microscopya (n = 260)

Prevalence

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

Positive

Negative

HRP2

 Positive

77

6

31.3 (25.7–37.3)

95.1 (87.8–98.6)

96.6 (92.8–98.8)

92.8 (85.4–96.6)

97.7 (94.3–99.1)

 Negative

4

173

Combo

 Positive

78

3

31.2 (25.9–37.2)

96.3 (89.6–99.2)

98.3 (95.2–99.7)

96.3 (89.4–98.8)

98.3 (95.1–99.4)

 Negative

3

176

  1. GS gold standard, PPV positive predictive value, NPV negative predictive value, HRP2 histidine-rich protein 2, pLDH lactate dehydrogenase
  2. aMean parasite density 29,721.6/µL (300–99,500/µL), Trophozoites 50, Schizont 1