Compound | Specificity | Mechanism of action | References |
---|---|---|---|
Bruceantin | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits initiation | |
Verrucarin A | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits initiation, binds between P- & A- sites | |
Suramin | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits initation & elongation, multiple binding sites | [18] Â |
Anisomycin | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits elongation, binds A-site | |
Cycloheximide | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits elongation, binds E-site | [13] |
Homoharringtonine | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits elongation on re-initiating ribosomes, binds A-site | |
Lactimidomycin | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits elongation, binds E-site | [13] |
Nagilactone C | Eukaryotic (Pf cytoplasmic ribosomes) | Inhibits elongation, binds A-site | |
Puromycin | Pan-inhibitor | tRNA mimetic | |
Halofuginone | Eukaryotic | Inhibits glutamyl-prolyl-tRNA synthetase | [22] |
Thiostrepton | Prokaryotic (Pf mitochondrial & apicoplast ribosomes) | Inhibits initiation & elongation |