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Table 3 Half-maximal effective concentrations (nM) determined in P. falciparum growth inhibition assay

From: The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

Test compounds

72H growth inhibition EC50 (nM)

Antimalarials

72H growth inhibition EC50 (nM)

Bruceantin

4.2

MMV008270

2400

Verrucarin A

0.6

SJ733

60

Suramin

1819

M5717 (DDD107498)

1

Anisomycin

39

Quinine

370

Cycloheximide

0.6

Chloroquine

333

Homoharringtonine

6.8

Mefloquine

25

Lactimidomycin

22

Piperaquine

26

Nagilactone C

1310

Primaquine

1849

Puromycin

52

Monodesethyl amodiaquinea

61

Halofuginone

 2

Lumefantrine

4

Thiostrepton

942

Dihydroartemisinin

3

Actinomycin D

10

  

Tubercidin

168

  

Thapsigargin

2900

  
  1. a Active metabolite of amodiaquine