Fig. 15From: The past, present and future of anti-malarial medicinesKey compounds in the discovery of SC83288. Initial modification of one amidino group with a sulfonamide linker (S2) resulted in improved solubility. Further modification of the remaining amidine group with substituted piperazine moieties ultimately led to the optimized compound with good solubility, permeability and high potencyBack to article page